# 2020 SFARI Collaboration on Sex Differences in Autism — Request for Applications

SFARI Collaborations are a new funding mechanism that will provide substantive and stable funding support to multidisciplinary teams of investigators tackling critical issues in the autism research field. Collaborations will be led by a director who oversees interdisciplinary, synergistic research efforts across multiple laboratories. Investigative groups within a Collaboration will focus on the same conceptually unified topic but will incorporate different scientific disciplines, multiple levels of analysis, and will include a robust data-sharing infrastructure.

SFARI Collaborations have a maximum budget of up to $8,000,000, including 20 percent indirect costs, over an initial period of four years, with a possible three-year extension. For our first Collaboration RFA, SFARI solicits applications to investigate sex differences in autism. Letter of Intent Deadline Maximum Budget Over Four Years$8,000,000

Important Dates
• Notification to Submit Full Application
• Notification to Present at SFARI
• In-Person Team Presentations
November or December 2020
January 2021
Contact Info
Maximum Budget

Over Four Years $8,000,000 Important Dates • Letter of Intent Deadline • Notification to Submit Full Application • Full Application Deadline • Notification to Present at SFARI • In-Person Team Presentations November or December 2020 • Award Notification January 2021 Contact Info ## SFARI Mission The mission of the Simons Foundation Autism Research Initiative (SFARI) is to improve the understanding, diagnosis and treatment of autism spectrum disorders (ASD) by funding innovative research of the highest quality and relevance. To this end, we solicit applications from scientific teams who will conduct bold and rigorous research. ## Background There is growing recognition that synergistic efforts across scientific disciplines will contribute to addressing the most critical questions in ASD research and accelerate progress on the development of therapeutics. SFARI Collaborations are a new funding mechanism that will provide substantive and stable funding support to multidisciplinary teams of investigators tackling critical issues in the autism research field. A proposal must address how the impact of a given Collaboration will be greater than the sum of what would be possible through awards to individual laboratories. Collaborations will be led by a director who oversees interdisciplinary, synergistic research efforts across multiple laboratories. Investigative groups within a Collaboration will focus on the same conceptually unified topic but will incorporate different scientific disciplines and multiple levels of analysis, and will include a robust data-sharing infrastructure. For our first Collaboration RFA, SFARI solicits applications to investigate sex differences in autism. SFARI expects to announce additional Collaboration RFAs in the future. ## Objective Although females may be underdiagnosed because of differences in presentation and/or diagnostic bias, there appears to be a substantial and consistent male bias in ASD prevalence that reflects differences between the sexes in susceptibility1–4. Among many potential explanations, female resilience could reflect a genetic buffering effect2, 5–7, or differences in hormone exposure8. Either of these possibilities could result in differences in cellular and/or circuit function between the sexes9–12. Considering the rapidly expanding knowledge of genetic and other risk factors in ASD, the stage seems set for significant advances in enhancing our understanding of the impact of sex on ASD risk and manifestations. For this SFARI Collaboration, we welcome proposals that will use an array of modern technologies to examine sex differences in brain function, within and across species, including humans, to identify key differences in gene, cell and circuit function that account for the observed differential sensitivities of the two sexes to ASD. A successful Collaboration must enhance our understanding of the biological bases for sex-specific differences in ASD and set the stage for development of novel interventions. ## Level and Duration of Funding SFARI Collaborations have a maximum budget of$8,000,000, including 20 percent indirect costs, over an initial period of four years, with a possible three-year extension. We also welcome applications from groups of investigators whose combined efforts do not require the maximum budget.

The financial structure is intended to accelerate progress by providing substantial flexibility in funding. Recognizing that different stages of a Collaboration may have different personnel and financial requirements, a Collaboration director may adjust principal investigator (PI) membership and funding levels to reflect scientific needs.

## Collaboration Structure

The Collaboration director is expected to determine the scientific agenda, coordinate the scientific activities of the other members, and manage the overall functioning of the Collaboration through administrative and data management teams. The director will be SFARI’s main point of contact for the activities of the collaboration and will be responsible for monitoring and reporting on the overall progress of the research effort and of the individual projects.

Principal investigators (PIs) are expected to conduct research that advances the goals of the Collaboration. Since inclusion of diverse viewpoints is critical for scientific advancement, SFARI strongly encourages the inclusion of researchers who span institutions, career stages and groups historically underrepresented in science.

SFARI’s scientific team will participate in annual meetings of the Collaboration at the Simons Foundation and will interact with the director and PIs to facilitate success of the Collaboration. Continued support for the Collaboration will be contingent upon progress toward the proposed aims as determined by SFARI.

## Application and Review Process

The selection process will occur in three stages:

1. Letter of Intent (LOI)
2. Full application
3. In-person team presentation to SFARI

Letter of Intent (LOI):

• Proposal Narrative: Four-page narrative describing scientific aims and how the results of the Collaboration will uniquely and synergistically contribute to our understanding of sex differences in autism. Collaboration objectives must be justified as major scientific milestones, and a timeline of activities should also be included. The project should have clearly defined initial activities and goals by which progress and success can be measured. Support from the Foundation should be seen as critical to achieving the objectives of the Collaboration. Applicants should include a brief description of how the project will be managed, including explicit efforts to facilitate collaboration among its members and how data will be shared within and beyond the Collaboration. Applicants are encouraged to utilize SFARI-generated resources, when appropriate, to advance the research goals.
• Team Summary: For the director, principal investigators and other key personnel, a description of their roles in the Collaboration, as well as a summary of the expertise, resources, collaboration history and the open-science practices they bring to the Collaboration should be provided.
• Biosketches: Biosketches for key personnel listed in the overview should be included.
• Budget Overview: For each proposed investigative site, a summary of major budgetary categories, including personnel, equipment and other essential resources, should be included.

The proposed Collaboration director will submit one LOI on behalf of the entire investigative team. The main criteria for evaluation will be the Collaboration’s potential scientific and translational impact, excellence of scientific leadership and investigative teams, and level of synergy and integration among the subprojects.

LOIs will be evaluated by the SFARI science team, and a subset of LOI applicants will be invited to submit full applications. Detailed instructions for full applications will be provided accordingly but, in brief, will include expanded descriptions of all subprojects, along with detailed budgetary information.

Full applications will be evaluated by an external review panel, and a subset of investigative teams will be invited to present their Collaboration proposal to the SFARI science team and invited scientists.

SFARI expects to award one or two Collaborations in response to this Sex Differences in Autism RFA.

## Instructions for Submission

Applications must be completed electronically and submitted using forms provided at proposalCENTRAL. Please log in as an applicant, go to the grant opportunities tab, scroll to “Simons Foundation,” and click apply now for the SFARI Collaborations Award. For assistance, please call 800-875-2562 or email pcsupport@altum.com.

Details concerning application requirements and submission can be found in our instructions or on proposalCENTRAL. If you have other questions, please review our FAQ.

## References

1. Lord C., Elsabbagh M., Baird G. & Veenstra-Vanderweele J. Lancet 392, 508–520 (2018) PubMed
2. Iossifov I. et al. Nature 515, 216–221 (2014) PubMed
3. Krumm N. et al. Am. J. Hum. Genet. 93, 595–606 (2013) PubMed
4. Werling D.M. & Geschwind, D.H. Mol. Autism 6, 27 (2015) PubMed
5. Jacquemont S. et al. Am. J. Hum. Genet. 94, 415–425 (2014) PubMed
6. Werling D.M. Biol. Sex Differ. 7, 58 (2016) PubMed
7. Doan R.N. et al. Nat. Genet. 51, 1092–1098 (2019) PubMed
8. Baron-Cohen S. et al. Mol. Psychiatry 20, 369–376 (2015) PubMed
9. Werling D.M., Parikshak, N.N. & Geschwind, D.H. Nat. Commun. 7, 10717 (2016) PubMed
10. Zeestraten E.A. et al. Transl. Psychiatry 7, e1090 (2017) PubMed
11. Jung H. et al. Nat. Neurosci. 21, 1218–1228 (2018) PubMed
12. Turner T.N. et al. Am. J. Hum. Genet. 105, 1274–1285 (2019) PubMed

The Simons Foundation uses an electronic grants submission process. All interested grant applicants must submit their applications online through proposalCENTRAL.

Maximum Budget

Over Four Years $8,000,000 Important Dates • Letter of Intent Deadline • Notification to Submit Full Application • Full Application Deadline • Notification to Present at SFARI • In-Person Team Presentations November or December 2020 • Award Notification January 2021 Contact Info The deadline for Letter of Intent (LOI) submission is Tuesday, April 21, 2020, 5:00 PM Eastern Time The prospective Collaboration Director (CD; see definition below) will submit one LOI on behalf of the entire investigative team. Accessing the Letter of Intent Application in proposalCENTRAL:4 Prospective applicants must submit a letter of intent (LOI) using the LOI application via proposalCENTRAL (pC). To start an application in pC, users must first log in to their pC account. If You Need to Create a New Account in pC To create a new account, go to https://proposalcentral.com/ (pC) and click create one now under need an account? Fill in the required fields, check the boxes to agree to pC’s “Terms of Service and Acceptable Use Policy” and then click “Save.” For the next steps, see the “If You Have an Existing Account in pC” section below. If You Have an Existing Account in pC For all users with a pC account, log in under “Application Login” at https://proposalcentral.com/ and select create new proposal or click on the grant opportunities tab. Scroll down to “Simons Foundation” and then click apply now for the Simons Foundation Autism Research Initiative-Collaborations Award program in order to start the proposal and access the templates. After all sections are completed, you will be able to click on the submit button. LOI Requirements and Submission Instructions To submit a letter of intent (LOI), the following proposalCENTRAL sections must be completed: 1. Title Page: Please provide the following information 1. Project title 2. Estimated annual budget, inclusive of all subprojects 3. Indicate use of SSC, Simons Searchlight or SPARK samples/phenotypic data. 4. Select a primary category. Please note a secondary category is not required. 2. Download Templates & Instructions: The following templates are available for download: 1. Letter of Intent (LOI) Instructions 2. SFARI Policies 3. Request for Applications (RFA) 4. LOI Proposal Narrative Template 5. Team Summary Template 6. Biosketch Template 7. Budget Overview Template 3. Enable Other Users to Access This Proposal: Complete this section to give administrators or collaborators access and to allow other users to submit the LOI on your behalf. 4. Applicant/Principal Investigator (PI): The collaboration director (CD) should be listed here. 5. Organization/Institution: The CD’s affiliated academic institution will be the lead institution. Contact information for the signing official and financial/fiscal officer from this institution is required; select the correct person or enter new names in this 6. Key Personnel: A Collaboration will consist of one Collaboration director, and a minimum of two (2) additional principal investigators (PIs). Each subproject must have a designated PI. Given the complexity of activities, the Foundation strongly encourages the inclusion of a project manager/coordinator who will work closely with the CD and the PIs to facilitate activities across the Collaboration. Additional key personnel may include but not be limited to: co-investigators, consultants, postdoctoral research associates and others. For more information on the personnel definitions, please refer to the SFARI RFA FAQ. 7. Attach Letter of Intent: The following documents are to be uploaded in the “Attach Letter of Intent” section, where they are also available for download: 1. LOI Proposal Narrative: The LOI narrative should not exceed four (4) pages of single-spaced, 11-point text, 0.5 margins. Please describe specific aims and how the results of the Collaboration will uniquely and synergistically contribute to our understanding of sex differences in autism. Collaboration objectives must be justified as major scientific milestones, and a timeline of activities should also be included. The project should have clearly defined initial activities and goals by which progress and success can be measured. Support from the Foundation should be seen as critical to achieving the objectives of the Collaboration. Applicants should include a brief description of how the project will be managed, including explicit efforts to facilitate collaboration among its members and how data will be shared within and beyond the Collaboration. Applicants are encouraged to utilize SFARI-generated resources, when appropriate, to advance the research goals. Figures, figure legends and tables are not included in the page limits and should be included in the narrative PDF document. References (formatted as in the Journal of Neuroscience, including full author list, title and link to PubMed) should be included at the end of the Proposal Narrative but will not count towards the page limit. 2. Team Summary: For the director, principal investigators and other key personnel, a description of their roles in the Collaboration, as well as a summary of the expertise, resources, collaboration history and the open-science practices they bring to the Collaboration should be provided. 3. Biosketches: Biosketches for each key personnel listed in the overview should be included. 4. Budget Overview: Summary of major budgetary categories, including personnel, equipment and other essential resources 8. PI Data Sheet: Required: the Collaboration director’s ORCID identifier. 9. Validate: You must click the validate button below to check for any missing required information or files. All missing required information will be listed on the screen. Please correct any missing information before proceeding to the next step. 10. Submit: You will be unable to submit if you have not provided all the required information. Any missing information will be listed on the screen. If your submission is successful, you will receive a confirmation message on the screen, and a confirmation email will be sent to your email address. 11. Please note that LOIs exceeding the four (4) page limit, excluding references, figures and figure legends, will not be reviewed. Review of applications Each LOI is evaluated by the SFARI science team, with additional advice from outside advisers as needed. A subset of LOI applicants will be invited to submit full applications. Detailed instructions for full applications will be provided accordingly but, in brief, will include expanded descriptions of all subprojects, along with detailed budgetary information. Full applications will be evaluated by an external review panel, and a subset of investigative teams will be invited to present their Collaboration proposal to the SFARI science team and invited scientists. Contacts  Scientific inquiries: sciencerfa@simonsfoundation.org 646-654-0066 Administrative inquiries: sfarigrants@simonsfoundation.org 646-654-0066 Simons collections inquiries: collections@sfari.org 646-654-0066 proposalCENTRAL: pcsupport@altum.com 800-875-2562 Maximum Budget Over Four Years$8,000,000

Important Dates