Innate Immune System Impact Request for Applications
Grants awarded through this RFA were intended to advance our understanding of the impact of activation of the innate immune system on behavioral, circuit, synaptic and neuronal functions in order to understand the consequences of infection and immune activation on autism-related behaviors. Experiments were expected to include physiologically relevant activation/inhibition of the innate immune system in animal models of autism and to focus on neuronal, synaptic and circuit function.
- Application Deadline
- Notification of Award
- Funding Expected to Begin
- Application Deadline
- Notification of Award
- Funding Expected to Begin
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SFARI Grant Programs
[email protected]
- Application Deadline
- Notification of Award
- Funding Expected to Begin
-
SFARI Grant Programs
[email protected]
Grants awarded through this request for applications (RFA) were intended to advance our understanding of the impact of activation of the innate immune system on behavioral, circuit, synaptic and neuronal functions in order to understand the consequences of infection and immune activation on autism-related behaviors.
To this end, we sought applications for investigations of the impact of physiologically relevant activation of the innate immune system on behavioral, circuit, synaptic and neuronal functions in animal models of autism. SFARI especially encouraged applications that address either of the following two issues:
(1) Effects of activation of the maternal innate immune system on embryonic central nervous system development in genetic models of autism and controls. How do fetal genetics and maternal innate immune activation interact to affect postnatal autism-related phenotypes, and what are the mechanisms through which they interact?
(2) Effects of activation of the innate immune system in genetic autism models and adult controls. How does innate immune activation affect behavioral, circuit, synaptic and cellular function in these genetic models and in controls? What are the roles of cytokine signaling, fever, immune cell activation and other effectors on these functions?
- Application Deadline
- Notification of Award
- Funding Expected to Begin
-
SFARI Grant Programs
[email protected]
Instructions for submission
Applications must be completed electronically and submitted using forms provided at proposalCENTRAL. Please log in as an applicant, scroll to ‘Simons Foundation’ and click on the program.
Contacts
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| Scientific inquiries: | [email protected] | 646-654-0066 |
| Administrative inquiries: | [email protected] | 646-654-0066 |
| proposalCENTRAL: | [email protected] | 800-875-2562 |
- Application Deadline
- Notification of Award
- Funding Expected to Begin
-
SFARI Grant Programs
[email protected]
-
Frequently Asked Questions
How do I submit a full proposal?
New users first need to register on proposalCENTRAL. For all users, log in and select “Create New Proposal” or click on the “Grant Opportunities” tab. Filter the Grant Maker by “Simons Foundation” and click on “Apply Now” next to the “Innate Immune System Impact” program. Once all sections are complete and the attachments are uploaded, the “Submit” button will be activated.
Are references, figures and figure legends included in the narrative six (6)-page limit? How should they be included?References, figures and figure legends are not included in the page limit for the full proposal. Please attach them at the end of the six (6)-page narrative in the same PDF file. The Simons Foundation’s preference is for figures to follow the narrative rather than be embedded in the text.
What are the font and size requirements?11-point, legible font.
What can I include as an appendix?‘In-press’ papers can be included as appendices, as well as any papers that you consider essential for the work of the review committee (not more than three [3]). Any other material should be included, if possible, in the narrative. If you have video attachments for your proposal, please upload as an appendix (all file types are accepted).
How can I find out more about available biospecimens and other data available from the Simons Variation in Individuals Project (Simons VIP) and Simons Simplex Collection (SSC)?You can access and request information about Simons VIP and SSC biospecimens and data on SFARI Base. If you do not have a SFARI ID, you must create one. If you have problems with the log-in or have questions about the availability of biospecimens or data, please email [email protected].
Does the Simons Foundation require letters of support or collaboration?We do not require letters of support or letters of collaboration for Co-investigators. If a letter is prepared, it can be uploaded as “Appendix: In-press papers on related topics.”
Is there a minimum percent effort for Principal Investigators or Co-investigators?There is no minimum percent effort required for any personnel, but we expect personnel, in particular Principal Investigators (PIs) and Co-investigators, to have efforts that reflect their roles in the project.
Can someone else (assistant, staff, etc.) submit my application for me?Yes, you can add users with administrator access to the proposalCENTRAL application so that someone other than the PI can edit and submit the application.
Can postdoctoral associates apply as PIs?No, postdoctoral associates may not apply. SFARI funds may only be used for personnel considered employees of the grantee institution who are eligible for benefits. Funds may not be used for stipend supplementation unless specifically authorized under the terms of the program from which funds are derived.
Can foreign institutions apply for a grant?Yes, foreign institutions with a 501(c)(3) equivalency may apply.
Can multiple PIs apply for a grant?The applicant organization may designate multiple individuals as PIs who share the authority and responsibility for leading and directing the project, intellectually and logistically. For more information on the responsibilities of PIs, please refer to the personnel definitions in the SFARI glossary below.
Applications with multiple PIs from different institutions that would like to be paid separately must include a signed signature page, budget template and budget justification for each PI. The budget totals for all non-applicant PIs must be included in the “Consortium and Contractual Direct Costs” section and indirect costs for all non-applicant PIs should be included in the “Other Indirect Costs” section.
Does the PI need to sign the signature page?No, only the signing official is required to sign the signature page.
What is required for a subcontract? Where do I add the subcontract budget and upload subcontract budget details?"Applications with subcontracts must submit a Subcontract Budget and Budget Justification for each subcontract awardee and grant year. The applicant PI must include the direct cost budget totals for all subcontracts in the “Consortium & Contractual Direct” section and indirect costs for all subcontracts in the “Other Indirect Cost” section. Please upload the subcontract budget details/budget justification (available for download in the “Proposal Attachments” section) in the “Proposal Attachments” section of the full application on proposalCENTRAL.
Can I make changes to the application once it has been submitted?You must contact the Simons Foundation to unsubmit your full application before you can edit attachments or HTML sections. Please email [email protected] or call 646-654-0066 if you would like to unsubmit your application prior to the 3 March 2014 deadline.
Is validating my proposal the same as submitting it?No. “Validating” the proposal checks for errors and omissions and will alert you to missing requirements of your application. If the application is complete, you must then click on “Submit.” You will receive an email within ten minutes, and should contact [email protected] if you do not receive confirmation and do not see your application in the “Submitted” tab or with the status changed to “Submitted.”
The deadline for notification has passed. What is the status of my proposal?You should receive notification within 24 hours of the deadline. Please check your spam filter settings if you have not received it by then.
Can PIs or Co-investigators submit multiple applications to the same award type (e.g. Pilot, Research, Explorer etc.)?You must request approval from the Science Team at [email protected].
Can PIs or Co-investigators apply to different award types (e.g. Pilot, Research, Explorer etc.)?You must request approval from the Science Team at [email protected].
Immune p38-alpha MAPK activation: Convergent mechanism linking autism models
- Awarded: 2014
- Award Type: Targeted: Innate Immune System
- Award #: 323427
- Randy Blakely, Ph.D. Florida Atlantic University
A probiotic therapy for autism
- Awarded: 2014
- Award Type: Targeted: Innate Immune System
- Award #: 322839
- Sarkis Mazmanian, Ph.D. California Institute of Technology
Immune signaling in the developing brain in mouse models of autism
- Awarded: 2014
- Award Type: Targeted: Innate Immune System
- Award #: 321998
- Kimberley McAllister, Ph.D. University of California, Davis
Synergy between genetic risk and placental vulnerability to immune events
- Awarded: 2014
- Award Type: Targeted: Innate Immune System
- Award #: 323220
- Theo Palmer, Ph.D. Stanford University