Autism genetics: Searching for coherence

  • Autism Research
Speaker Daniel Geschwind, M.D., Ph.D.
University of California, Los Angeles
Date & Time


Location

Gerald D. Fischbach Auditorium
160 5th Avenue
New York, NY 10010 United States

Autism Research

Autism Research lectures bring together scientists and scholars to discuss diverse and important topics related to autism.

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On 28 November, Daniel Geschwind discussed his group’s use of RNA sequencing, chromatin structure and gene networks to help develop an understanding of potential convergent mechanisms in autism spectrum disorders.

His talk is part of the Simons Foundation Autism Research lecture series.

About the Lecture

The understanding of autism spectrum disorder as a range of disorders, rather than a singularity, raises the question of whether conditions of the disorders converge on common molecular pathways.

In this lecture, Daniel Geschwind discussed his group’s use of RNA sequencing, chromatin structure and gene networks to help develop an understanding of potential convergent mechanisms in autism spectrum disorders. He illustrated how knowledge of chromatin structure informs the understanding of gene regulation during human brain development and disease-associated, non-coding variation.

Geschwind described his lab’s work leveraging multiple transcriptomic datasets and gene network analyses to predict how risk genes for autism spectrum disorders affect the development and function of brain circuits. His group now uses this framework to explore convergence and divergence with other neuropsychiatric disorders

About the Speaker

Daniel Geschwind is the Gordon and Virginia MacDonald Distinguished Professor of Human Genetics, Neurology and Psychiatry at the University of California, Los Angeles. He leads the university’s Institute for Precision Health as senior associate dean and associate vice chancellor of precision health. Geschwind has fostered large-scale collaborative patient resources for genetic research and data sharing in autism research and his laboratory helped pioneer the application of systems biology methods in neurologic and psychiatric diseases. He is an elected member of both the Association of American Physicians and the National Academy of Medicine.

Past Lectures

Rare variants and the genetics of autism

Evan E. Eichler, Ph.D.Professor, Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle

Evan Eichler discussed his research on the genetics of autism and related neurodevelopmental conditions.

Phenotyping sleep

Emmanuel Mignot, M.D., Ph.D.Craig Reynolds Professor of Sleep Medicine, Stanford University

Emmanuel Mignot discussed sleep biology as well as sleep disorders and their impact. He presented a link to what is known on the genetics of sleep and sleep disorders. He emphasized the need for large scale objective sleep recording studies with genomic and proteomic analysis to better understand the molecular pathways regulating sleep and circadian biology.

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