Autism genetics: Searching for coherence

  • Autism Research
Speaker Daniel Geschwind, M.D., Ph.D.
University of California, Los Angeles
Date & Time


Location

Gerald D. Fischbach Auditorium
160 5th Avenue
New York, NY 10010 United States

Autism Research

Autism Research lectures bring together scientists and scholars to discuss diverse and important topics related to autism. The lectures are open to the public and are held at the Gerald D. Fischbach Auditorium at the Simons Foundation headquarters in New York City. Tea is served prior to each lecture.

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On 28 November, Daniel Geschwind discussed his group’s use of RNA sequencing, chromatin structure and gene networks to help develop an understanding of potential convergent mechanisms in autism spectrum disorders.

His talk is part of the Simons Foundation Autism Research lecture series.

About the Lecture

The understanding of autism spectrum disorder as a range of disorders, rather than a singularity, raises the question of whether conditions of the disorders converge on common molecular pathways.

In this lecture, Daniel Geschwind discussed his group’s use of RNA sequencing, chromatin structure and gene networks to help develop an understanding of potential convergent mechanisms in autism spectrum disorders. He illustrated how knowledge of chromatin structure informs the understanding of gene regulation during human brain development and disease-associated, non-coding variation.

Geschwind described his lab’s work leveraging multiple transcriptomic datasets and gene network analyses to predict how risk genes for autism spectrum disorders affect the development and function of brain circuits. His group now uses this framework to explore convergence and divergence with other neuropsychiatric disorders

About the Speaker

Daniel Geschwind is the Gordon and Virginia MacDonald Distinguished Professor of Human Genetics, Neurology and Psychiatry at the University of California, Los Angeles. He leads the university’s Institute for Precision Health as senior associate dean and associate vice chancellor of precision health. Geschwind has fostered large-scale collaborative patient resources for genetic research and data sharing in autism research and his laboratory helped pioneer the application of systems biology methods in neurologic and psychiatric diseases. He is an elected member of both the Association of American Physicians and the National Academy of Medicine.

Past Lectures

Progress in understanding the genetic basis of mental health

Benjamin Neale, Ph.D.Associate Professor, Analytic and Translational Genetics Unit, Massachusetts General Hospital
Associate Professor in Medicine, Harvard Medical School
Associated Researcher, Broad Institute

On May 6, 2020, Benjamin Neale discussed progress in mapping genetic risk factors for autism, schizophrenia and bipolar disorder.

Autism, autisms, or neurodevelopmental disorders?

Jason Lerch, Ph.D.Director of Preclinical Imaging, Wellcome Centre for Integrative Neuroimaging, University of Oxford
Adjunct Scientist, Mouse Imaging Centre, The Hospital for Sick Children
Associate Professor in Medical Biophysics, University of Toronto

On January 29, 2020, Jason Lerch explored this question: What do modern ways of looking at brains and genes tell us about autism – or autisms – and its relation to attention deficit disorder, obsessive-compulsive disorder and other related disorders of brain development?

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