Recent SFARI-funded research challenges the idea that autism represents a single condition driven by a uniform set of genetic risk factors. Instead, the results support a developmental framework in which distinct constellations of polygenic influences are linked to different diagnostic timelines.
SFARI-funded research demonstrates that activating serotonergic 5HT2c receptors leads to an increase in intracellular calcium, early-response gene expression and elevated protein secretion into cerebrospinal fluid.
SFARI-funded research finds that RAPGEF4 is a key molecular regulator orchestrating prefrontal cortical maturation in primates.
The Simons Foundation Autism Research Initiative (SFARI) is pleased to announce a new data release from Simons Searchlight aimed at improving the scientific understanding of autism.
SFARI-funded research finds that demonstrates that SCN8A mutations underlying DEE-13 disrupt both cortical and hippocampal networks, but in distinct ways.
On September 29, 2025, the SFARI Autism Rat Consortium (ARC) held its annual meeting in the Usher Institute of the University of Edinburgh. This year’s event brought together ARC PIs and trainees who specialize in the use of rat models.
Simons Searchlight offers open-source data and tools to researchers worldwide who study autism and related neurodevelopmental conditions.
Last spring, members of the Simons Foundation’s Fellows-to-Faculty program met for the 2025 meeting to share their latest findings and make connections.
Simons Foundation Fellows-to-Faculty alumnus Tomasz Nowakowski spoke with the foundation about his experiences with the program.
Simons Foundation Fellows-to-Faculty Fellow Gabriela Rosenblau spoke with the foundation about her experiences with the fellowship.