SFARI | Topic: Molecular Mechanisms

Patterned cPCDH expression regulates the fine organization of the neocortex.

Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells.

An in vivo platform for rebuilding functional neocortical tissue.

Systematic multi-trait AAV capsid engineering for efficient gene delivery.

Epithelia delimits glial apical polarity against mechanical shear to maintain glia-neuron architecture.

Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons.

Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways.

CHD8 suppression impacts on histone h3 lysine 36 trimethylation and alters rna alternative splicing.

Classifying axon pathology in autism using machine learning and deep neural network analyses

In the current project, Basilis Zikopoulos and Arash Yazdanbakhsh plan to use sophisticated methodologies of machine learning to classify white matter cortical pathways in postmortem brain tissue samples from individuals with ASD and neurotypical individuals. Results from this study will provide novel data on key features of typical cortical white matter pathways and axon pathology in ASD.

Cellular resolution multi-omics of white matter tracts in autism

White matter tracts are brain regions that have been understudied at the cellular and molecular level yet are clearly functionally altered in individuals with ASD. In the current project, Genevieve Konopka plans to assess the molecular make-up of the cellular constituents of white matter tracts in postmortem brain tissue from individuals with ASD compared with neurotypical individuals.