Molecular Mechanisms

PI(4,5)P₂-dependent and Ca²⁺-regulated ER-PM interactions mediated by the extended synaptotagmins

DNA methylation presents distinct binding sites for human transcription factors.

Dendritic arborization and spine dynamics are abnormal in the mouse model of MeCP2 duplication syndrome.

TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation.

Topoisomerases facilitate transcription of long genes linked to autism.

MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.

Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.

AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder.

Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking.

Alternative splicing of the pituitary adenylate cyclase-activating polypeptide receptor PAC1: Mechanisms of fine tuning of brain activity.

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