Molecular Mechanisms

Microglia in the cerebral cortex in autism.

Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders.

Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95.

PTEN signaling in autism spectrum disorders.

Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities.

The E3 ubiquitin ligase protein associated with Myc (PAM) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.

Functional regulation of GABA_A receptors in nervous system pathologies.

Neurexin and neuroligin mediate retrograde synaptic inhibition in Celegans.

Optogenetic control of phosphoinositide metabolism.

CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium.

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