Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.
Molecular Mechanisms
Elevated polygenic burden for autism is associated with differential DNA methylation at birth.
Foxp1 regulation of neonatal vocalizations via cortical development.
Modeling the interplay between neurons and astrocytes in autism using human induced pluripotent stem cells.
A map of human mitochondrial protein interactions linked to neurodegeneration reveals new mechanisms of redox homeostasis and NF-kB signaling.
Mouse Model of Dup15q Syndrome
Oxytocin receptor signaling
Moses Chao will investigate how the oxytocin receptor transduces its signals in the brain to generate its physiological and behavioral effects, by exploring the signaling properties of the oxytocin receptor and its potential association with neurotrophin-related pathways. This project is directly relevant to understanding the mechanism of neuropeptides and their impact upon autism spectrum disorders, anxiety and social behavior.
In vitro modeling of genetic subtypes of autism
Stessman aims to use human cell lines engineered to express patient mutations to determine how these genes contribute to disease etiology, particularly during early development of the human brain. These cell lines will also be a useful tool for therapeutic development in the future.
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.
Prediction and interpretation of deleterious coding variants in terms of protein structural stability.
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