Activity regulates cell death within cortical interneurons through a calcineurin-dependent mechanism.
Molecular Mechanisms
Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon.
Autism BrainNet: A network of postmortem brain banks established to facilitate autism research.
Developmental diversification of cortical inhibitory interneurons
Rbfox splicing factors promote neuronal maturation and axon initial segment assembly
Network analysis of UBE3A/E6AP-associated proteins provides connections to several distinct cellular processes.
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.
A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry.
Temporal control of mammalian cortical neurogenesis by m6A methylation.
Biophysical characterization of KCC2
The neuron-specific potassium-chloride co-transporter, KCC2, is involved in the regulation of excitatory and inhibitory neuronal activity. It has been identified as a promising therapeutic target for autism. In the current project, Charles Craik’s laboratory and collaborators plan to determine the high-resolution structure of KCC2 with the intention of developing strategies to regulate its activity.
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