Cell biology of astrocyte-synapse interactions.
Molecular Mechanisms
Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment.
Disc1 regulates neurogenesis via modulating kinetochore attachment of Ndel1/Nde1 during mitosis.
Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.
Elevated polygenic burden for autism is associated with differential DNA methylation at birth.
Foxp1 regulation of neonatal vocalizations via cortical development.
Modeling the interplay between neurons and astrocytes in autism using human induced pluripotent stem cells.
A map of human mitochondrial protein interactions linked to neurodegeneration reveals new mechanisms of redox homeostasis and NF-kB signaling.
Mouse Model of Dup15q Syndrome
Oxytocin receptor signaling
Moses Chao will investigate how the oxytocin receptor transduces its signals in the brain to generate its physiological and behavioral effects, by exploring the signaling properties of the oxytocin receptor and its potential association with neurotrophin-related pathways. This project is directly relevant to understanding the mechanism of neuropeptides and their impact upon autism spectrum disorders, anxiety and social behavior.
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