Synthesis and evaluation of a new 18F-labeled radiotracer for studying the GABAB receptor in the mouse brain.
Molecular Mechanisms
Genome-wide CRISPR-Cas9 interrogation of splicing networks reveals a mechanism for recognition of autism-misregulated neuronal microexons.
Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes.
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.
m6A facilitates hippocampus-dependent learning and memory through YTHDF1.
Brain organoids and the study of neurodevelopment.
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development.
p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.
Rbfox1 mediates cell-type-specific splicing in cortical interneurons.
Cell type molecular neuropathology of the cerebellum in autism
While clinical and pathological studies of individuals diagnosed with ASD have repeatedly implicated the cerebellum in ASD pathogenesis, whole-tissue analyses have not found differences in gene expression between ASD and unaffected cerebellar tissue. Kathleen Millen, in collaboration with Kimberly Aldinger, plans to use state-of-the-art single-cell and bulk tissue RNA sequencing to fully define the molecular and cellular diversity across all cell types within the cerebellum in ASD.
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