Cell type specific roles of FOXP1 during early neocortical murine development.
Molecular Mechanisms
Cell-type-specific effects of autism-associated 15q duplication syndrome in the human brain.
A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus.
Unveiling the role of IGF1R in autism spectrum disorder: a multi-omics approach to decipher common pathogenic mechanisms in the IGF signaling pathway.
Reactivating FMR1 to treat fragile X syndrome
Assessing the role of the autism risk gene Gigyf1 in astrocytic regulation of postnatal brain development in mice
Piloting gene- and mutation-specific antisense oligonucleotide therapies for autism
Identifying the epigenetic vulnerability of neurodevelopment
Oligodendrocyte dysfunction in mouse models of autism
Cell-specific phosphoproteomic profiling in a mouse model of autism linked to a dysregulated kinase
Our project is a proof-of-concept study to determine differences in the phosphorylation status of proteins in different striatal cell types in a novel mouse model of the Okur-Chung neurodevelopmental syndrome that is driven by a mutation in the kinase CK2. The aim is to ascertain if master signal transduction pathways can be identified that are differentially regulated in specific neuron types, which is of crucial importance when developing novel therapeutical approaches for ASD.
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