Genetics

Determining how rare and common variants interact and contribute to risk for autism

Autism is a highly polygenic disorder in which multiple classes of genetic variation — ranging from common variants with small effects to highly penetrant copy number variants and de novo exonic variants — contribute to risk. Growing evidence suggests an interplay between rare and common variants. Hyejung Won, Kristen Brennand and Nan Yang aim to study the biological underpinning of how common and rare variants interact to contribute to ASD risk.

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