SFARI | Topic: Circuits, Cognition & Behavior

Ketamine induces multiple individually distinct whole-brain functional connectivity signatures.

Mapping human social brain specialisation beyond the neuron using multimodal imaging in human infants.

A new theoretical framework jointly explains behavioral and neural variability across subjects performing flexible decision-making.

Ventral striatal dopamine encodes unique properties of visual stimuli in mice.

Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity.

Cortical-subcortical interactions in goal-directed behavior.

Cell-type specific transcriptomic signatures of neocortical circuit organization and their relevance to autism.

Precision psychiatry requires disentangling disorder-specific variation: The case of ASD.

Cortico-cerebellar communication during flexible motor control in mouse models of autism

Adam Hantman and colleagues plan to apply established behavioral training and characterization techniques, as well as neural recording and perturbation methods, to monitor neural activity across the cortico-cerebellar network in three established genetic mouse models of ASD. The central hypothesis of the project is that disrupted cortico-cerebellar communication underlies impairments in motor control and behavioral flexibility in ASD.

Developing Rat MoSeq to characterize autism models

Sandeep Robert Datta and colleagues seek to understand how mutations in genes implicated in ASD influence the behavior of rats. To do so, they plan to take advantage of new machine learning-based tools to quantitatively dissect the behavior of ASD genetic rat models before and after social experience. The team’s hope is that understanding how ASD risk genes impact behavior will lead to a deeper understanding of the neural basis of ASD.