Maternal immune activation alters visual acuity and retinogeniculate axon pruning in offspring mice.
Circuits, Cognition & Behavior
Comprehensive behavioral phenotyping of a 16p11.2 del mouse model for neurodevelopmental disorders.
Sex differences in salience network connectivity and its relationship to sensory over-responsivity in youth with autism spectrum disorder.
Assessing the role of predictive processing in autism using electrophysiological modeling of neural responses to natural speech
Many people on the autism spectrum have difficulty processing everyday sensory information. In the current project, Edmund Lalor aims to explore the underlying causes of this difficulty by analyzing brain responses to predictable and unpredictable speech in adolescents with and without autism. In doing so, the project also aims to produce clinically useful measures of sensation, perception and language function in people with autism.
Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants.
Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature.
Directed information exchange between cortical layers in macaque V1 and V4 and its modulation by selective attention.
Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks.
Input-output relationship of CA1 pyramidal neurons reveals intact homeostatic mechanisms in a mouse model of fragile X syndrome.
Neural mechanisms underlying sleep disturbances in Syngap1+/- mutant mice
Shinjae Chung and Ted Abel will assess the neural dynamics of sleep neurons in Syngap1 mutant mice, aiming to understand how changes in their activity lead to sleep disturbances and behaviors associated with autism.
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