SFARI | Topic: Circuits, Cognition & Behavior

Motor training improves coordination and anxiety in symptomatic MECP2-null mice despite impaired functional connectivity within the motor circuit.

Dopaminergic dysregulation in syndromic autism spectrum disorders: Insights from genetic mouse models.

Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin.

Bottom-up inputs are required for establishment of top-down connectivity onto cortical layer 1 neurogliaform cells.

Placental endocrine function shapes cerebellar development and social behavior.

T1-weighted/T2-weighted ratio mapping at 5 months captures individual differences in behavioral development and differentiates infants at familial risk for autism from controls.

Lateralized decrease of parvalbumin+ cells in the somatosensory cortex of ASD models is correlated with unilateral tactile hypersensitivity.

Critical windows and reversibility of autism associated with mutations in chromatin remodelers

A significant proportion of ASD risk genes encode proteins that function as chromatin modifiers. In the current project, Gaia Novarino plans to study conditional mouse models of two ASD risk genes in this class: ASH1L and KMT5B. She plans to study their roles during development and in adulthood, as well as assess whether any of the observed phenotypes are reversible. Such analyses are critical to developing novel therapeutic strategies for individuals with ASD associated with mutations in this class of genes.

Social behavior in prepubertal neurexin 1α deficient rats: A model of neurodevelopmental disorders.

Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD.