Circuits, Cognition & Behavior

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Fronto-striatal dopamine underlying behavioral inhibition in a mouse model of neurofibromatosis type 1

Impulsivity, the inability to suppress inappropriate behaviors, is a hallmark of executive control and a feature of autism spectrum disorder (ASD). Adam Kepecs’ project aims to establish a new model system to study behavioral inhibition, one that combines neurofibromatosis-1 mouse models with a quantitative cross-species behavioral paradigm to understand the role of dopamine in impulsivity.

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