By assessing the 16p11.2 deletion autism mouse model, Ted Abel and colleagues uncover male-specific vulnerabilities in striatal signaling and reward function.
Lukens and Zunder will utilize transcriptomics, mass cytometry and data-driven science to uncover cellular and molecular underpinnings of sex bias in an MIA model of autism.
Presentations that will be given by SFARI Investigators at the 2017 International Meeting for Autism Research (IMFAR) in San Francisco (May 10-13) are highlighted.
SFARI is pleased to announce that it has awarded 27 grants (21 Pilot Awards and 6 Research Awards) in response to the 2016 Pilot and Research Awards request for applications.
By examining SNPs from ASD datasets, Lauren Weiss finds that genetic mechanisms regulating general sex differences, such as height and weight, contribute to autism risk.
Autism spectrum disorder (ASD) is diagnosed in boys 4-5 times more frequently than in girls. Many factors contribute to this gender bias, but the origins of the biological factors remain largely unknown. Sex differences in the expression of candidate risk genes may underlie at least some of this bias, but these differences have not been explored.