Tag: SCN2A

Understanding the neurobiology of attachment deficits in ASD

Devanand Manoli’s group has developed tools to determine how mutations in individual genes cause specific deficits in social attachment in prairie voles. In this project, they will generate voles with mutations in SCN2a, which has been highly correlated with ASD, and determine the patterns of social attachment deficits in these animals; then, they will manipulate neurons expressing OXTR to determine if modulation of their activity can ameliorate deficits in attachment behaviors resulting from loss of SCN2a function.

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