Tag: neural circuits

SFARI workshop revisited the excitation-inhibition hypothesis of autism On May 15, 2018, SFARI convened a workshop to revisit the excitation/inhibition (E/I) hypothesis of autism, a synaptic-based account of the disorder that has been highly influential in the last…

Striatal circuit dysfunction in a mouse model of the autism risk gene CACNA1D Anis Contractor will assess how the development of synapses and circuits in the striatum are disrupted in a novel mouse model of autism that harbors a gain-of-function mutation in the…

Assessing sensory impairments and aberrant cortical circuit activity in Cntnap2 knockout mice Bilal Haider plans to measure intact cortical circuit activity during quantifiable sensory and behavioral impairments in Cntnap2 knockout mice — a genetically relevant model of autism spectrum disorder (ASD). Findings…

Identifying convergent cortical circuit impairments across multiple mouse models of autism Jess Cardin and Michael J. Higley will establish a functional screen (using a CRISPR/Cas9-induced gene disruption system and multiscale in vivo calcium imaging in awake mice) for the assessment of…

Establishment of specific cortico-basal ganglia circuits by autism-linked protocadherins Hisashi Umemori will use knockout mouse models to identify the roles played by a group of ASD-linked protocadherins in regulating specific cortico-striatal circuits, aiming to reveal novel molecular and circuit…

Sensory circuit development in a zebrafish model of fragile X syndrome Geoffrey Goodhill will address how the early development of neural sensory circuits is altered in autism spectrum disorders, using a zebrafish model of fragile X syndrome to examine alterations in…