Jun Huh, Gloria Choi and colleagues provide a link between maternal infection, gut bacteria and the risk of developing behavioral and cortical abnormalities in mice.
SFARI is pleased to announce that it has awarded 32 grants (19 Pilot Awards and 13 Research Awards) in response to the 2017 Pilot and Research Awards request for applications (RFA).
Choi proposes to use the MIA mouse model with a discrete, functionally relevant lesion in the primary somatosensory cortex to elucidate neural circuits that modulate ASD-associated behaviors.
The Noonan lab will systematically identify ASD regulatory networks in the developing brain at high resolution, revealing cellular and developmental mechanisms underlying ASD risk.
Rubenstein will identify how defects in brain development are caused by ASD mutations in Pogz and Suv420h1, genes involved in chromatin remodeling and transcriptional silencing.