Tag: cortex

Exploring regulatory genomic variation in the developing human brain to understand autism Jonathan Mill’s project aims to characterize multiple layers of gene regulation during brain development, facilitating a systematic exploration of hypotheses related to the neurodevelopmental origins of autism. Further, by characterizing…

New mathematical approaches to dissect neuronal circuit alterations in Rett syndrome using EEG data Electroencephalogram (EEG) scalp recordings are one of the most common measures of brain activity, but EEG data lacks cellular resolution. Stefano Panzeri aims to develop new mathematical models based on…

Neuroscience 2018: Presentations by SFARI Investigators SFARI Investigators will be giving a number of presentations at Neuroscience 2018 in San Diego, CA (November 3–7).

Assessing sensory impairments and aberrant cortical circuit activity in Cntnap2 knockout mice Bilal Haider plans to measure intact cortical circuit activity during quantifiable sensory and behavioral impairments in Cntnap2 knockout mice — a genetically relevant model of autism spectrum disorder (ASD). Findings…

Identifying convergent cortical circuit impairments across multiple mouse models of autism Jess Cardin and Michael J. Higley will establish a functional screen (using a CRISPR/Cas9-induced gene disruption system and multiscale in vivo calcium imaging in awake mice) for the assessment of…

Developmental origins of the female protective effect in autism Autism spectrum disorder (ASD) is diagnosed four times as often in boys compared than girls, but the developmental mechanisms that lead to this male bias have not been elucidated. Jessica…