Tag: cortex

Development of a single-cell mouse cortical gene expression pattern resource that identifies putative brain disorder subtypes Mark Zylka and colleagues generated single-cell RNA-seq data from wild-type mouse cortex during early development and demonstrated how such a resource can be used to identify putative brain disorder subtypes…

SFARI presentations at INSAR 2019 SFARI Investigators and SFARI science staff will be giving a number of oral presentations at the International Society for Autism Research (INSAR) 2019 Annual Meeting in Montreal, Canada (May 1-4).

Mapping human cerebral cortex: Structure, function, connectivity, development and evolution

In vivo calcium dynamics in dendritic spines of Shank3 and Scn2a mutant mouse models of autism Converging lines of evidence suggest that dendritic spine pathology is a common feature in ASD. Alex Kwan will use advanced optical imaging methods in awake behaving mice to determine how…

Elucidating the role of chromatin-modifying complexes in autism spectrum disorder Pierre Mattar proposes to identify and characterize how chromatin-remodeling enzymes regulate neurogenesis in the developing brain and how dysfunction in these complexes contribute to ASD. Specifically, his team aims to…

The influence of ASD risk genes on corticostriatal circuit development and reinforcement learning Linda Wilbrecht proposes that an inability to appropriately update behavior based on probabilistic feedback represents a core learning deficit in ASD and that specific frontal-striatal circuits may contribute to these…