Tag: cortex

Enhancement of neurexin-1 function in a genetic mouse model: A novel approach to restore synaptic pathways disrupted in autism Genetic studies of ASD implicate alterations in synaptic development and signaling, with the synaptic protein neurexin-1 playing a pivotal role. Ann Marie Craig aims to develop new approaches to overcome…

SFARI Winter 2019 Pilot awardees announced SFARI is pleased to announce that it intends to fund 15 grants in response to the Winter 2019 Pilot Award request for applications (RFA).

Exploring regulatory genomic variation in the developing human brain to understand autism Jonathan Mill’s project aims to characterize multiple layers of gene regulation during brain development, facilitating a systematic exploration of hypotheses related to the neurodevelopmental origins of autism. Further, by characterizing…

New mathematical approaches to dissect neuronal circuit alterations in Rett syndrome using EEG data Electroencephalogram (EEG) scalp recordings are one of the most common measures of brain activity, but EEG data lacks cellular resolution. Stefano Panzeri aims to develop new mathematical models based on…

Neuroscience 2018: Presentations by SFARI Investigators SFARI Investigators will be giving a number of presentations at Neuroscience 2018 in San Diego, CA (November 3–7).

Analysis of UBE3A- and NHE6-mutant cells to determine social communication gene networks A major challenge for autism research is to establish convergent mechanisms that group apparently distinct genetic etiologies. Through investigation and comparison of transcriptome profiles, Eric Morrow aims to identify genetic…