Tag: brain imaging

A Conversation with Paul Wang, Deputy Director of Clinical Research Associates Paul Wang, Deputy Director of Clinical Research Associates, L.L.C. (CRA), discusses the research that CRA supports, including human and animal studies using arbaclofen, a potential drug treatment for autism.

Characterizing focal cortical dysplasias in individuals with autism spectrum disorders Using new magnetic resonance imaging techniques and analysis approaches to identify focal cortical dysplasias (FCDs), Ruth Carper aims to determine whether FCDs occur more frequently in individuals with ASDs than…

Conserved neural mechanisms for social motivation in mice and humans Rebecca Saxe will test whether midbrain dopaminergic signals of social cravings, previously observed in mice, are similarly observed in humans. As impairments in social motivation have been postulated to be…

Development of a biomarker of disrupted GABAergic signaling in autism Caroline Robertson’s laboratory aims to develop a neurophysiological marker of autism that reflects reductions in GABAergic action in the autistic brain. Such a marker will help shed light on the…

Integrative characterization of microglial and astrocyte activation in autism Michael Gandal’s project combines basic science and translational investigations to provide a comprehensive characterization of the spatiotemporal trajectory, functional significance and translational potential of glial cell activation in autism.

Linking placental dysfunction, cerebellar white matter alterations and social behavior deficits in a novel mouse model Anna Penn will assess cerebellar white matter and circuitry alterations in a new mouse model that lacks placental expression of the neurosteroid allopregnanolone. These changes will be compared to those…