Mechanisms of disrupted cortical functional connectivity in a mouse model of CDKL5 deficiency disorder
Neural circuits of frustration and aggression
Aggression is the most common reason for hospitalization in children with autism, yet little is known about the neurobiology of aggression in autism, and current treatment options are grossly inadequate. In this project, Neir Eshel and colleagues plan to use a mouse model to explore the roles of dopamine and serotonin in controlling aggressive responses to frustration.
Retrospective longitudinal characterization of gene expression changes in mouse models of autism
Autism can be caused by dysregulated gene expression during development. In the current project, Reza Kalhor plans to create in vivo longitudinal recordings of target gene expression as the mouse brain develops in a series of increasingly complex differentiation and patterning events. Gene expression changes in neurotypical and mouse models of autism will be compared to aid in our understanding of how the foundation for autism phenotype is laid during embryogenesis.
Assessing the role of the autism risk gene Gigyf1 in astrocytic regulation of postnatal brain development in mice
Parvalbumin interneuron deficits in MTORpathies associated with ASD
Gut-intrinsic mechanisms of gastrointestinal dysmotility in animal models of autism
Linking ASD risk genes to sensorimotor circuits for dynamic social
The role of microglia on aberrant neuronal network formation in autism spectrum disorder
Longitudinal in vivo CRISPRi screen for abnormal molecular and circuit maturation of intratelencephalic cortical neurons in ASD
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