Simons Searchlight Phase 1 was conducted from 2010 to 2014 and consisted of in-person assessments at clinical sites across the U.S. At that time, the study was called Simons Variation in Individuals Project (Simons VIP). This program started with a focus on the 16p11.2 deletion and duplication, later adding individuals with a 1q21.1 deletion or duplication as a small pilot. The project initially chose to focus on these genetic variations because of their relatively high occurrence in autism cohorts and because their straightforward identification from DNA microarrays made recruitment feasible.

Data from Phase 1 are still available to researchers. Available Phase 1 resources includes:

• Single nucleotide polymorphism (SNP) genotype data
• Targeted sequencing data
• Whole-exome sequencing data
• Whole-genome sequencing data
• MRI/fMRI/MEG imaging
• Plasma biospecimens
• In-depth phenotyping

A list of neuropsychological tests and other phenotypic instruments used in data collection for Phase 1 can be found . More information on phenotypic and neuropsychiatric data can be found in the researcher welcome packet.

Interested investigators can request access to all this data through SFARI Base.