Simons Searchlight

Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder.

Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses.

Human iPSC-derived neuron of 16p11.2 deletion reveals haplotype-specific expression of MAPK3 and its contribution to variable NDD phenotypes.

Rare CNVs and phenome-wide profiling: A tale of brain-structural divergence and phenotypical convergence.

Spontaneous neural activity relates to psychiatric traits in 16p11.2 CNV carriers: An analysis of EEG spectral power and multiscale entropy.

Contrastive machine learning reveals the structure of neuroanatomical variation within autism.

Consistency of parent-report SLC6A1 data in Simons Searchlight with provider-based publications.

Characterization of phenotypic range in DYRK1A haploinsufficiency syndrome using standardized behavioral measures.

Multi-omic analysis along the gut-brain axis points to a functional architecture of autism.

16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis.