Tyne Miller-Fleming is a molecular and statistical geneticist in the Division of Genetic Medicine and Clinical Pharmacology, Department of Medicine, at Vanderbilt University Medical Center (VUMC). She received her Ph.D. in neuroscience from Vanderbilt University, where her thesis work focused on characterizing the molecular determinants of synapse removal in GABAergic neurons in C. elegans. After completing her doctoral degree, Miller-Fleming joined the Division of Genetic Medicine for a postdoctoral fellowship with Nancy Cox and Lea Davis through the Vanderbilt Genomic Medicine training program. During this time, she expanded her skills to include computational and statistical genetic approaches in human disease, including the analysis of genotype and whole-exome sequencing data, genome-wide association studies, polygenic risk score calculations and imputation of gene expression. Additionally, she gained experience analyzing phenotype data extracted from medical records through phenotype algorithms, phenome-wide association studies, generation of phenotype risk scores, and laboratory-wide association scans.

Miller-Fleming’s current research as a research instructor in medicine at VUMC aims to utilize EHR-linked genetic data to understand the genetic and phenotypic relationships underlying neurodevelopmental disorders (NDDs). She is interested in disentangling complex comorbidity patterns across NDDs and examining the relationship between common and rare genetic variation contributing to the clinical manifestations of neurodevelopmental phenotypes.