Stefan Strack, Ph.D.

John Paul Long Professor and Vice Chair, Department of Neuroscience and Pharmacology , University of Iowa

SFARI Investigator Website

Stefan Strack is the John Paul Long Professor and vice chair in the Department of Neuroscience and Pharmacology at the University of Iowa. Born and raised in Germany, he received his Ph.D. at the State University of New York at Albany and his postdoctoral training at Vanderbilt University before joining the faculty at the University of Iowa in 2000.

Strack’s current research focuses on the regulation of mitochondrial dynamics by protein kinases and phosphatases in normal brain function and neurological diseases and injuries such as stroke. A second area of research interest are neurodevelopmental disorders caused by de novo mutations in signaling enzymes, including protein kinases, phosphatases and ubiquitin ligases.

Strack is committed to training the next generation of scientists and directs a National Institute of General Medical Sciences (NIGMS)-funded predoctoral training program (T32) in pharmacological sciences.

Funded Projects

Molecular signatures and reversibility in mouse models of Jordan’s syndrome

Awarded: 2021
Award Type: Pilot

SFARI Funded Publications

De novo missense variants in the PP2A regulatory subunit PPP2R2B in a neurodevelopmental syndrome: Potential links to mitochondrial dynamics and spinocerebellar ataxias. Sandal P., Jong C.J., Merrill R.A., Kollman G.J., Paden A.H., Bend E.G., Sullivan J., Spillmann R.C., Shashi V., Vulto-van Silfhout A.T., Pfundt R., de Vries B.B.A., Li P.P., Bicknell L.S., Strack S.

Astrocyte mitochondria are a sensitive target of PCB52 and its human-relevant metabolites. Paranjape N., Strack S., Lehmler H.-J., Doorn J.A.

B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan’s syndrome mutations Wu C.-G., Balakrishnan V.K., Merrill R.A., Parihar P.S., Konovolov K., Chen Y.-C., Xu Z., Wei H., Sundaresan R., Cui Q., Wadzinski B.E., Single M.R., Musiyenko A., Chung W.K., Hokanen R.E., Suzuki A., Huang X., Strack S., Xing Y.