Image Giorgia Quadrato

Giorgia Quadrato, Ph.D.

Assistant Professor, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California

SFARI Scientific Review Board Website

Giorgia Quadrato’s laboratory focuses on understanding the cellular and molecular basis of human brain development and disease. They aim to improve emerging brain-region specific models of the human brain, including pluripotent stem cell-derived 3-D organoids and human chimeric mice and to combine them with large-scale single-cell omics technologies to: (i) study how cell-cell interactions affect the establishment of functional circuits during human brain development; (ii) investigate how perturbation of neuronal activity affects cell-cell and cell-extracellular matrix interactions in distinct neural subtypes; (iii) understand how cell-type-specific cellular programs that control activity-dependent cell-cell interactions are disrupted in neurodevelopmental disorders; and (iv) explore the potential neurodevelopmental origins of neurodegenerative disorders, focusing on the selective vulnerability of distinct neural cell types.

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