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Timing mechanisms of critical periods in brain development

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

  On 30 September 2015, Takao Hensch discussed the biological bases of critical periods in brain development. Mechanisms that open and close windows of plasticity (E/I balance and molecular brakes, respectively) have been implicated in autism, suggesting mistimed maturational processes that can be strategically rescued at the circuit level. His talk was part of the...

SFARI Society for Neuroscience 2015 Social

Hyatt Regency Chicago Downtown Regency Ballroom A 151 E Upper Wacker Dr, Chicago, IL, United States

  All Society for Neuroscience (SfN) attendees are welcome to join SFARI Investigators and scientific staff for an evening of socializing and networking, including a brief information session on SFARI funding programs and scientific resources for the autism research community. We welcome newcomers to autism research as well as those already working to uncover the...

Molecular and neural architecture of circuits underlying social behavior in the mouse

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

  On 28 October 2015, Catherine Dulac discussed the cellular and molecular architecture of neural circuits underlying instinctive social behaviors in mice. Her talk was part of the Simons Foundation Autism Research lecture series. About the Lecture Severe mental disorders such autism spectrum disorders, schizophrenia and major depressive disorder are characterized by profound social impairments. There...

Storming the ivory tower: How to make autism interventions work in schools

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

  On 11 November 2015, David S. Mandell talked about why autism interventions rarely are implemented in community practice and why they fail to achieve the same outcomes as those observed in clinical trials. His talk was part of the Simons Foundation Autism Research lecture series. About the Lecture A growing body of research shows...

Making up your mind: Interneurons in development and disease

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

  On 27 January 2016, Gordon Fishell described his investigations of the developmental and genetic origins of interneuron development. His talk was part of the Simons Foundation Autism Research lecture series. About the Lecture Interneurons within the brain, in the cortex and hippocampus in particular, are central for normal brain function, and conversely, dysfunction of...

Development begins before birth: Prenatal research relevant to autism

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

  On 30 March 2016, Catherine Monk described her lab’s fetal origins of adult disease (FOAD) studies that focus on women in the perinatal period and fetal and infant neurobehavioral development, including direct studies of the fetus, newborn brain imaging and placental methylation. Her talk was part of the Simons Foundation Autism Research lecture series....

One brain, many genomes: Somatic mutation and genomic variability in human cerebral cortex

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

  On 27 April 2016, Christopher Walsh reviewed recent work on ‘somatic mutations’ — de novo mutations that are present in some brain cells but not in all cells of the body — in several neurological conditions associated with intellectual disability and seizures. His talk was part of the Simons Foundation Autism Research lecture series....

Sleep in autism spectrum disorders: A window to etiology, diagnosis and treatment

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

  On 7 September 2016, Ruth O'Hara discussed the field’s current understanding of sleep in autism spectrum disorder. Her talk was part of the Simons Foundation Autism: Emerging Concepts lecture series. About the Lecture Understanding sleep physiology in autism spectrum disorder (ASD) not only provides a window to the underlying etiology, it can also help...

Tuberous Sclerosis: Shedding light on the neural circuitry of autism

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

  On 5 October 2016, Mustafa Sahin presented an update on translational research in Tuberous Sclerosis Complex. His talk was part of the Simons Foundation Autism Research lecture series. About the Lecture In this lecture, Mustafa Sahin presented the rationale for investigating Tuberous Sclerosis Complex (TSC) as a way to understand the cellular and circuitry...

How immune cells help wire the brain: Implications for autism and psychiatric illness

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

  On 2 November 2016, Beth Stevens discussed recent work that implicates brain immune cells, called microglia, in sculpting of synaptic connections during development and their relevance to autism, schizophrenia and other brain disorders. Her talk was part of the Simons Foundation Autism Research lecture series. About the Lecture Recent research has revealed a key...

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