Tag: 16p11.2

February 24, 2022

Human derived 3D brain cultures provide insights into brain size changes in 16p11.2 conditions By Kris Dickson

January 28, 2022

Simons Searchlight: December 2021 data release

December 17, 2021

SFARI 2021 Pilot awardees announced

Neuromuscular junction. Fluorescent confocal light micrograph of the junction between a nerve cell and a muscle (not seen). The axon of the nerve cell (neuron) has been tagged with a blue dye. The axon ends at end plates, which form junctions called synapses with the muscle cells. The end plates have been dyed red here by tagging them with the snake venom alpha-bungarotoxin, which binds to them. When a nerve signal reaches the synapse, it causes the synaptic vesicles to rupture, releasing the neurotransmitter acetylcholine. The protein synaptophysin, found in the vesicles, is dyed green. Acetylcholine binds to receptors on the muscle cells, causing them to contract. Magnification: x120 when printed 10cm wide.

December 13, 2021

New iPSC lines from Simons Searchlight participants are now available

November 22, 2021

Altered hormone signaling in the brainstem causes motor delays in 16p11.2 mice By Kris Dickson

November 16, 2021

RhoA over activation may underlie smaller brain volumes in Cul3 mutant mice By Kris Dickson