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X-WR-CALDESC:Events for SFARI
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DTSTART:20140101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20141029T170000
DTEND;TZID=UTC:20141029T181500
DTSTAMP:20260513T181701
CREATED:20141029T080000Z
LAST-MODIFIED:20180216T202333Z
UID:1995-1414602000-1414606500@www.sfari.org
SUMMARY:Microbiota and the host immune system in autism
DESCRIPTION:  \n\nOn 29 October 2014\, Dan Littman described how intestinal bacteria affect immune system cell functioning\, potentially contributing to systemic inflammation and autism. \nHis talk was part of SFARI’s Autism: Emerging Concepts lecture series. \nAbout the lecture:\nOur immune system is heavily influenced by microbiota — the microbes that reside within us. In the intestine\, specific microbes induce pro- or anti-inflammatory white blood cells called lymphocytes that maintain a healthy homeostasis. An imbalance of microbiota can result in dysregulated immune cells that contribute to autoimmunity and autism. \nIn this lecture\, Dan Littman described how intestinal bacteria shape the part of the immune system that prevents invasion by harmful microbes\, but they can also contribute to systemic inflammation. The bacteria regulate Th17 cells\, which participate in multiple autoimmune diseases. These cells play a key role in the maternal immune activation model of autism. Activation of the pregnant mother’s innate immune response may result in lifelong behavioral defects in the child. Through this lens\, Littman discussed implications for preventing or treating autism. \nAbout the speaker:\nDan Littman earned his M.D. and Ph.D. from Washington University in St. Louis\, completing a postdoctoral fellowship with Richard Axel at Columbia University. From Columbia\, he moved to the University of California\, San Francisco\, where he  was professor of microbiology and immunology. Littman is now the Helen L. and Martin S. Kimmel Professor of Molecular Immunology at the Skirball Institute of Biomolecular Medicine at New York University and an investigator at the Howard Hughes Medical Institute. \n  \n 
URL:https://www.sfari.org/event/microbiota-and-the-host-immune-system-in-autism/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/sites/2/2017/07/04172630/DanLittman250.jpg
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