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X-WR-CALDESC:Events for SFARI
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DTSTART:20130101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20130530T170000
DTEND;TZID=UTC:20130530T181500
DTSTAMP:20260505T084529
CREATED:20130530T080000Z
LAST-MODIFIED:20180216T203256Z
UID:1991-1369933200-1369937700@www.sfari.org
SUMMARY:Antibodies\, behavior and cognition
DESCRIPTION:  \n\n\n\n\n\n\n\nOn 30 May\, Betty Diamond discussed how the immune system can mediate alterations in brain development and play a role in autism\, as part of SFARI’s Autism: Emerging Concepts lecture series. \nAlan Brown provided a post-lecture commentary and context for Diamond’s work on epidemiological studies of autism and related disorders. \nYou can watch a complete video recording of the event above. Use the comments section below to discuss the lecture and pose follow-up questions. \nAbout the lecture:\nAs neutralizers of microbial agents\, antibodies are major contributors to immune competence. Occasionally\, however\, they act as autoantibodies\, which bind to a person’s own tissue\, triggering autoimmune disease. In adults\, the blood-brain barrier protects the brain against autoantibodies\, but that barrier is not fully competent in fetuses\, allowing maternal antibodies to penetrate the fetal brain and potentially alter its development. This mechanism may contribute to some cases of autism. \nAbout the speaker:\nBetty Diamond is head of the Center for Autoimmune and Musculoskeletal Diseases at the Feinstein Institute for Medical Research in New York. Her research has focused on the induction and pathogenicity of anti-DNA antibodies in systemic lupus erythematosus. She received the American College of Rheumatology’s Distinguished Investigator Award in 2001\, the Lee C. Howley Sr. Prize from the Arthritis Foundation in 2002\, and the Recognition Award from the National Association of M.D.-Ph.D. Programs in 2004. Diamond was elected to the Institute of Medicine in 2006. \nAbout the commentator:\nAlan S. Brown is professor of psychiatry and epidemiology at Columbia University and director of the Unit in Birth Cohort Studies at the New York State Psychiatric Institute. His research has focused on prenatal exposure to infectious\, immunologic\, nutritional and toxic factors\, and its association with risk of schizophrenia\, bipolar disorder and autism. He demonstrated earlier this year that elevated maternal C-reactive protein\, an inflammatory biomarker\, is related to a significantly increased risk of autism in the child. He is leading large\, multi-site national birth cohort studies of prenatal biomarkers\, developmental pathways and familial vulnerability based on an archived biobank and nationwide registries in Finland. \n  \n  \n 
URL:https://www.sfari.org/event/antibodies-behavior-and-cognition/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/sites/2/2013/05/29134615/BettyDiamond550.jpg
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BEGIN:VEVENT
DTSTART;TZID=UTC:20130425T170000
DTEND;TZID=UTC:20130425T181500
DTSTAMP:20260505T084529
CREATED:20130425T080000Z
LAST-MODIFIED:20180216T203322Z
UID:1992-1366909200-1366913700@www.sfari.org
SUMMARY:New genetic insights into autism
DESCRIPTION:  \n\n\n\nOn 25 April 2013\, Matthew State reviewed the genetic discoveries made over the past several years in autism research and addressed challenges in the path forward — from reliable gene discovery to an actionable understanding of the disorder’s molecular underpinnings.The talk is part of SFARI’s Autism: Emerging Concepts lecture series. You can watch a complete video recording of the event above. Use the comments section below to discuss the lecture and pose follow-up questions. \nAbout the lecture:\nThe genetics of autism has reached a tipping point. The recent focus on de novo mutations — or genetic variations not passed on from either parent — has led to systematic\, highly productive gene discovery efforts. This work has begun to clarify a tremendously heterogeneous genetic architecture as well as to reveal specific genes contributing to social disability syndromes. \nAbout the speaker:\nMatthew State received his undergraduate and medical degrees from Stanford University and completed his residency in psychiatry and fellowship in child psychiatry at the University of California\, Los Angeles\, Neuropsychiatric Institute. He received his Ph.D. in genetics from Yale University and was a faculty member there from 2001 to 2013. He is currently chair of psychiatry at the University of California\, San Francisco. \nState’s lab has a long-standing interest in the contribution of rare genetic mutations to childhood neuropsychiatric disorders\, including autism and Tourette syndrome. He is currently leading a large\, multisite\, genome-wide study of autism funded by the Simons Foundation and is playing a leadership role in the Tourette International Collaborative for Genetics and the Autism Sequencing Consortium. Among many professional honors\, he has been awarded the Ruane Prize for Outstanding Research in Child and Adolescent Psychiatry by the Brain and Behavior Research Foundation. \n  \n  \n 
URL:https://www.sfari.org/event/new-genetic-insights-into-autism/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/sites/2/2017/07/04174421/MatthewState250.jpg
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