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DTSTART:20160101T000000
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DTSTART;TZID=UTC:20161005T170000
DTEND;TZID=UTC:20161005T181500
DTSTAMP:20260513T152757
CREATED:20161005T080000Z
LAST-MODIFIED:20180216T201810Z
UID:1998-1475686800-1475691300@www.sfari.org
SUMMARY:Tuberous Sclerosis: Shedding light on the neural circuitry of autism
DESCRIPTION:  \nOn 5 October 2016\, Mustafa Sahin presented an update on translational research in Tuberous Sclerosis Complex. His talk was part of the Simons Foundation Autism Research lecture series. \nAbout the Lecture\nIn this lecture\, Mustafa Sahin presented the rationale for investigating Tuberous Sclerosis Complex (TSC) as a way to understand the cellular and circuitry alterations underlying autism spectrum disorder. Using a combination of cell culture\, mouse behavior and human electroencephalography (EEG) and magnetic resonance imaging (MRI) experiments\, Sahin and colleagues have demonstrated abnormalities in neuronal connectivity and neuron-glia interactions in TSC. Inhibitors of mammalian target of rapamycin (mTOR) proteins are effective in mouse models of TSC and are being tested in clinical trials now. A better understanding of TSC can also provide insights for related neurodevelopmental disorders in which similar cellular and circuit abnormalities can be detected. \nAbout the Speaker\nMustafa Sahin is a developmental neurobiologist and a pediatric neurologist. He received his B.S. degree from Brown University\, his M.D. and Ph.D. from Yale School of Medicine. He completed a pediatrics residency at Children’s Hospital of Philadelphia and a child neurology residency at Boston Children’s Hospital. He is currently the director of the Translational Neuroscience Center at Boston Children’s Hospital and a professor of neurology at Harvard Medical School. He directs two national consortia to study biomarkers and comparative pathobiology of TSC and related neurodevelopmental disorders. \n  \n  \n  \n 
URL:https://www.sfari.org/event/tuberous-sclerosis-shedding-light-on-the-neural-circuitry-of-autism/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/sites/2/2017/07/04170403/MustafaSahin250.jpg
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